Dermatologists and Pharamacists

The science behind Xantho

COSMECEUTICALS based on hop extract rich in Xanthohumol

The skin is constantly exposed to UV light, pollutants and other sources of oxidative stress. When the oxidative stress on the skin becomes too great, the skin is damaged.(1,2) This results in the ageing process speeding up whereby the skin’s moisture and its function as a barrier are impaired.(3)

The epidermis and dermis are skin layers that are most exposed to oxidative stress. It is critical that antioxidants reach these layers if they are to carry out their function fully.

Polyphenols are generally considered the most potent antioxidants to bind with free radicals.(4,5) Free radicals affect cell structures and membranes. Hop polyphenols, including Xanthumol, have the capacity to bind with these free radicals. It has been demonstrated that the anti-oxidative capacity of xanthoumol is 10 to 20 times greater than that of quercetin and 5 to 6 times greater than that of resveratol.(6) It has been shown that xanthohumol is the strongest anti-oxidant. It has also been demonstrated that hop polyphenols have stronger anti-oxidative characteristics than do polyphenols in green tea.(7)

Because of these strong anti-oxidative characteristics, xanthohumol can significantly slow down the ageing process.

Xanthohumol also contributes to an improvement in the skin structure and skin strength by inhibiting elastase and matrix metalloproteinases and stimulating the biosynthesis of extra-cellular matrix components, collagen fibrilis, elastine and fibrils.(8)

Xantho care products contain an extract from the hop plant that is rich in xanthohumol, the strongest antioxidant in the plant world.

Thanks to our patented formulation, we have successfully optimised the availability of the xanthohumol to the skin.(9)

Xantho care products are cosmeceuticals that contain active components that improve the skin’s appearance and structure.

These new formulations were moreover developed from two perspectives: KEEP IT SIMPLE and FROM A PHARMACIST’S POINT OF VIEW. This perspective involves the use of a limited number of well-defined excipients. Thanks to a patented technology, the poorly water-soluble substance xanthohumol is made optimally available to the skin.(9)

References

  1. Wysocki et al., Skin anatomy, physiology, and pathophysiology. Nurs. Clin. North Am, 34, 777-797 (1999).
  2. Sander et al., Photoaging is associated with protein oxidation in human skin in vivo. J. Investigat. Dematol. 118, 618-625 (2002).-
  3. Kuwazuru et al., Skin wrinkling morpology changes suddenly in the early 30s. Skin Res. Technol., 18, 495-503 (2012).
  4. Halliwell, Antioxidants in human health and disease. Annual Review of Nutrition, 16, 33-50 (1996).
  5. Seifried et al., Review of the interaction among dietary antioxidants and reactive oxygen species. Journal of Nutritional Biochemistry, 18, 567-579 (2007).
  6. van Hoyweghen et al. Radical scavenging capacity of hop-derived products. 63, 1-5 (2010).
  7. Wang et al., In vitro and in vivo antioxidant and antimutagenic activities of polyphenols extracted from hops (Humulus lupulus L.). 94, 1693-1700 (2013).
  8. Philips et al., Direct inhibition of elastase and matrixmetalloproteinases and stimulation of biosynthesis of fibrillar collagens, elastin, and fibrillins by xanthohumol. J. Cosmet. Sci, 61, 125-132 (2010).
  9. Remon, Xanthohumol-based compositions, PCT/EP2018/059423, publication date 18.10.2018.

 

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